Charlie Heller (Rami Malek) is a brilliant but deeply introverted decoder for the CIA who works in a basement office at Langley headquarters. His life is turned upside down when his wife is killed in a terrorist attack in London. When his superiors refuse to intervene, he takes matters into his own hands and embarks on a dangerous journey around the world to track down those responsible, using his intelligence as his ultimate weapon to escape his pursuers and take revenge.